Second harmonic Doppler ultrasound blood perfusion measurement
- Resource Type
- Authors
- M. Victor; V. Uhlendorf; Vernon L. Newhouse; S. Dubin; Beth Schrope
- Source
- IEEE 1992 Ultrasonics Symposium Proceedings.
- Subject
- Photoacoustic Doppler effect
symbols.namesake
Nuclear magnetic resonance
Materials science
In vivo
Echo (computing)
Harmonic
symbols
Blood volume
Doppler ultrasound
Perfusion
Doppler effect
- Language
In vivo testing of a recently introduced method of evaluating blood perfusion is presented, where the Doppler shift of the second harmonic component of the backscattered echo is measured. Central to this measurement is the administration of a galactose-based contrast agent which has been shown in vitro to exhibit extraordinary nonlinear backscattering properties. In vivo studies on living rabbits are described, in which blood perfusion is manipulated by various mechanisms to obtain some indication of the quantitative ability of the measurement. It is shown that use of the second harmonic measurement results in a greatly superior ratio of blood echo intensity to tissue echo intensity, allowing real-time determination of blood volume fluctuations in tissue. >