ObjectiveThe aim of this study was to assess the efficacy of gaseous cryotherapy following total knee arthroplasty (TKA) and to compare it to routinely used strategies for applying cold therapy.Patients and methodsSixty-six patients undergoing primary unilateral TKA were randomized into three groups and received “gaseous cryotherapy (GC)”, “cold pack” and “cryocuff” applications, respectively throughout the hospital stay. Primary outcomes (knee pain intensity, mobility and girth measurements) were recorded on preoperative day 1 as well as on postoperative day (POD) 7. Cutaneous temperature of the knee sides were also measured on POD7 just before and immediately after cold application.ResultsAlthough skin temperature dropped to 14°C following GC versus 22 to 24°C for the other two applications (P