A multi-institutional outbreak of New Delhi metallo-β-lactamase–producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene
- Resource Type
- Authors
- Benjamin P Howden; Aaron Walton; Yehuda Carmeli; M Lindsay Grayson; Sammy Frenk; David Schwartz; Jason C Kwong; Elizabeth Temkin; Norelle L Sherry; Mitchell J. Schwaber; Ester Solter
- Source
- Infection Control & Hospital Epidemiology. 42:1124-1127
- Subject
- Microbiology (medical)
0303 health sciences
biology
030306 microbiology
Epidemiology
Klebsiella pneumoniae
Outbreak
biology.organism_classification
medicine.disease_cause
Metallo β lactamase
DNA sequencing
Microbiology
03 medical and health sciences
0302 clinical medicine
Infectious Diseases
medicine
New delhi
030212 general & internal medicine
Escherichia coli
Gene
- Language
- ISSN
- 1559-6834
0899-823X
We characterized 57 isolates from a 2-phase clonal outbreak of New Delhi metallo-β-lactamase–producing Eschericha coli, involving 9 Israeli hospitals; all but 1 isolate belonged to sequence-type (ST) 410. Most isolates in the second phase harbored blaKPC-2 in addition to blaNDM-5. Genetic sequencing revealed most dual-carbapenemase–producing isolates to be monophyletically derived from a common ancestor.