Nanophotonics enhanced coverslip for phase imaging in biology
- Resource Type
- Authors
- Jingchao Song; Timothy J. Davis; Jieqiong Lou; Lukas Wesemann; Elizabeth Hinde; Ann Roberts; Jon Rickett
- Source
- Light, Science & Applications
Light: Science & Applications, Vol 10, Iss 1, Pp 1-6 (2021)
- Subject
- Medical diagnostic
Nanophotonics and plasmonics
Letter
business.industry
Nanophotonics
Phase (waves)
Imaging and sensing
QC350-467
02 engineering and technology
Optics. Light
021001 nanoscience & nanotechnology
01 natural sciences
Atomic and Molecular Physics, and Optics
TA1501-1820
Electronic, Optical and Magnetic Materials
Visualization
010309 optics
0103 physical sciences
Phase imaging
Optoelectronics
Applied optics. Photonics
0210 nano-technology
business
Human cancer
- Language
- English
- ISSN
- 2047-7538
2095-5545
The ability to visualise transparent objects such as live cells is central to understanding biological processes. Here we experimentally demonstrate a novel nanostructured coverslip that converts phase information to high-contrast intensity images. This compact device enables real-time, all-optical generation of pseudo three-dimensional images of phase objects on transmission. We show that by placing unstained human cancer cells on the device, the internal structure within the cells can be clearly seen. Our research demonstrates the significant potential of nanophotonic devices for integration into compact imaging and medical diagnostic devices.
The nanophotonics enhanced coverslip (NEC) enables ultra-compact phase imaging of samples placed directly on top of the device. Visualization of artificial phase objects and unstained biological cells is demonstrated.