Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity
- Resource Type
- Authors
- Giulia Guiducci; Lovorka Stojic
- Source
- Trends in genetics : TIG. 37(6)
- Subject
- Genome instability
0303 health sciences
Genome integrity
Cell division
DNA Repair
Cell growth
Cell Cycle
Computational biology
Cell cycle
Biology
Genomic Instability
03 medical and health sciences
0302 clinical medicine
Neoplasms
Genetics
Animals
Humans
Causal link
RNA, Long Noncoding
Gene
030217 neurology & neurosurgery
030304 developmental biology
Genome stability
DNA Damage
- Language
- ISSN
- 0168-9525
The cell cycle is controlled by guardian proteins that coordinate the process of cell growth and cell division. Alterations in these processes lead to genome instability, which has a causal link to many human diseases. Beyond their well-characterized role of influencing protein-coding genes, an increasing body of evidence has revealed that long noncoding RNAs (lncRNAs) actively participate in regulation of the cell cycle and safeguarding of genome integrity. LncRNAs are versatile molecules that act via a wide array of mechanisms. In this review, we discuss how lncRNAs are implicated in control of the cell cycle and maintenance of genome stability and how changes in lncRNA-regulatory networks lead to proliferative diseases such as cancer.