Insufficient expression of the melanocortin-1 receptor by human dermal fibroblasts contributes to excess collagen synthesis in keloid scars
- Resource Type
- Authors
- Qiong Zhou; Ying Shi; Tiechi Lei; Shi-Zheng Xu; Long-Fei Luo
- Source
- Experimental Dermatology. 22:764-766
- Subject
- Pathology
medicine.medical_specialty
Dermatology
Biochemistry
Transforming Growth Factor beta1
Keloid
medicine
Humans
Fibroblast
Receptor
Molecular Biology
Skin
Wound Healing
Chemistry
Fibroblasts
medicine.disease
Hedgehog signaling pathway
medicine.anatomical_structure
Gene Expression Regulation
alpha-MSH
Cell culture
Cancer research
Melanocytes
Collagen
Receptor, Melanocortin, Type 1
Myofibroblast
Signal Transduction
Hormone
Melanocortin 1 receptor
- Language
- ISSN
- 0906-6705
Activation of the α-melanocyte-stimulating hormone (αMSH)/melanocortin-1 receptor (MC1R) signalling pathway exerts antagonistic actions on cutaneous inflammatory and fibrogenic responses in addition to promoting pigment production. Herein, the expression of MC1R by keloid-derived fibroblasts and keloid scar tissue was investigated using a range of techniques. MC1R mRNA expression levels in five different keloid fibroblast cell lines were significantly reduced to less than half compared with five normal fibroblast cell lines (P