A composite of graphene oxide and iron oxide nanoparticles for targeted drug delivery of temozolomide
- Resource Type
- Authors
- Li-Hua, Wang; Lin, Sui; Peng-Hui, Zhao; Hai-Di, Ma; Jia-Yuan, Liu; Zhen, Wei; Zai-Ji, Zhan; Yong-Li, Wang
- Source
- Die Pharmazie. 75(7)
- Subject
- Drug Carriers
Drug Liberation
Drug Delivery Systems
Brain Neoplasms
Cell Line, Tumor
Temozolomide
Animals
Graphite
Magnetic Iron Oxide Nanoparticles
Glioma
Antineoplastic Agents, Alkylating
Cell Proliferation
Rats
- Language
- ISSN
- 0031-7144
A magnetic targeting nanoparticle based on graphene oxide-ferroferric oxide (GO-Fe₃O₄) was investigated as a potential drug delivery vehicle. The formation of GO/Fe₃O₄ hybrid material was confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy and transmission electron microscopy. The GO/Fe₃O₄ hybrid still shows a higher saturation magnetization of 58.42 emu/g after coating with graphene oxide. Drug loading and releasing experiments demonstrate the GO-Fe₃O₄ hybrid has a good loading capacity of (6.47±0.08) mg/mg for temozolomide and a satisfactory release under slightly acidic condition. The MTT assays of glioma C6 cells exhibits the GO-Fe₃O₄ hybrid does not display toxicity with the concentration ranged from 40 to 120 μg/mL