Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions
- Resource Type
- Authors
- Jingyu Zhang; Hang Gong; Feng Zhang; Lesong Li
- Source
- Scientific Reports, Vol 9, Iss 1, Pp 1-6 (2019)
Scientific Reports
- Subject
- 0301 basic medicine
Multidisciplinary
Solvent free
Chemistry
lcsh:R
lcsh:Medicine
Article
Metal
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
0302 clinical medicine
Yield (chemistry)
Amide
visual_art
visual_art.visual_art_medium
Organic chemistry
lcsh:Q
Formamides
lcsh:Science
030217 neurology & neurosurgery
Gram
- Language
- English
- ISSN
- 2045-2322
This study described an efficient and practical approach for amide synthesis. The reaction was conducted under metal- and solvent-free conditions at a mild temperature (40 °C) in air, and readily available formamides were used as an amino source. This reaction can be easily upgraded to the gram level with an excellent yield.