Slower early response to treatment and distinct expression profile of childhood high hyperdiploid acute lymphoblastic leukaemia with DNA index < 1.16
- Resource Type
- Authors
- Martina Vaskova; Jan Stary; Lenka Hovorkova; Marketa Zaliova; Ondrej Hrusak; Jan Zuna
- Source
- Genes, Chromosomes and Cancer. 55:727-737
- Subject
- 0301 basic medicine
Oncology
Genetics
Cancer Research
medicine.medical_specialty
dnaI
Chromosome
Dna index
Biology
medicine.disease
Response to treatment
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
030220 oncology & carcinogenesis
Internal medicine
Gene expression
medicine
Ploidy
Trisomy
Gene
- Language
- ISSN
- 1045-2257
Acute lymphoblastic leukaemias (ALL) with 51-67 chromosomes are defined as high hyperdiploid (HHD) and are generally associated with good prognosis. However, several studies show heterogeneity in HHD ALL and suggest that the favourable prognosis is associated rather with higher ploidy defined by DNA index (DNAi) ≥ 1.16 or with a presence of specific single or combined trisomies. HHD ALL with DNAi < 1.16 are only rarely studied separately. Using single nucleotide polymorphism array, we analysed 89 childhood HHD ALL patients divided into groups with lower (