Hemophagocytic lymphohistiocytosis in an HIV-positive patient with concomitant disseminated histoplasmosis
- Resource Type
- Authors
- Rachna Jetly; Brianna Oliver; Taylor Smith; Lee S. Engel; Nisha Loganantharaj; Shane E. Sanne
- Source
- International journal of STDAIDS. 29(9)
- Subject
- Male
Pediatrics
medicine.medical_specialty
Antifungal Agents
Constitutional symptoms
Human immunodeficiency virus (HIV)
Dermatology
medicine.disease_cause
Histoplasmosis
Lymphohistiocytosis, Hemophagocytic
03 medical and health sciences
0302 clinical medicine
Disseminated histoplasmosis
hemic and lymphatic diseases
Amphotericin B
Antiretroviral Therapy, Highly Active
HIV Seropositivity
medicine
Humans
Pharmacology (medical)
030212 general & internal medicine
Hemophagocytic lymphohistiocytosis
business.industry
Public Health, Environmental and Occupational Health
Middle Aged
medicine.disease
Positive patient
Infectious Diseases
Treatment Outcome
030220 oncology & carcinogenesis
Concomitant
Itraconazole
business
Elevated ferritin
- Language
- ISSN
- 1758-1052
A 46-year-old Dominican man, known to have HIV, presented with constitutional symptoms of two week's duration. The patient was found to have cytopenias, significantly elevated ferritin level and lymphadenopathy. Biopsies and laboratory studies met the criteria for hemophagocytic lymphohistiocytosis (HLH). A concomitant diagnosis of histoplasmosis was confirmed as the trigger for HLH and treatment resulted in clinical improvement and resolution of symptoms.