Magnetic mesoporous silica nanospheres with dual proberelease fluorescent functionality
- Resource Type
- Authors
- Gabriel Ybarra; Diego Muraca; Octavio Garate; Lionel S. Veiga; Leandro M. Socolovsky; Pablo Tancredi; Patricia C. Rivas-Rojas
- Source
- Nanotechnology. 31(49)
- Subject
- Materials science
Mechanical Engineering
Nanoparticle
Bioengineering
Nanotechnology
General Chemistry
Mesoporous silica
Nanomaterials
Mechanics of Materials
Covalent bond
Molecule
Magnetic nanoparticles
General Materials Science
Electrical and Electronic Engineering
Dispersion (chemistry)
Layer (electronics)
- Language
- ISSN
- 1361-6528
The combination of different nanomaterials through step-by-step synthesis procedures has turned into a promising alternative to fabricate high-quality nanosystems in order to satisfy the increasingly demanding requirements of the biomedical field. In this work, we report a detailed study on the synthesis and characterization of a complex nanosystem composed of nanoparticles with a single magnetic nanoparticle core and a shell of dense and mesoporous silica arranged in layers. The procedure designed to fabricate these systems lead us to the formation of a dispersion of non-agglomerated spherical nanoparticles of nearly 100 nm. The structural characterization performed over the final samples confirmed both the prevalence of single-core systems and the presence of the mesoporous silica shell in the outer layer. The performance of the nanosystem in a specific technological application was tested by sequentially loading two different fluorescents molecules by covalent and non-covalent bonding strategies. Due to the distinct loading strategies, the resulting nanosystem presented a magnetically-assisted probe & release functionality as analyzed in a magnetophoretic experiment.