LDL-C: The Only Causal Risk Factor for ASCVD. Why Is It Still Overlooked and Underestimated?
- Resource Type
- Authors
- Lamija Ferhatbegović; Denis Mršić; Sabina Kušljugić; Belma Pojskić
- Source
- Current Atherosclerosis Reports. 24:635-642
- Subject
- Cardiovascular Diseases
Risk Factors
Humans
Cholesterol, LDL
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Atherosclerosis
Cardiology and Cardiovascular Medicine
Dyslipidemias
- Language
- ISSN
- 1534-6242
1523-3804
Low-density lipoprotein cholesterol (LDL-C) is the most important causal risk factor for atherosclerotic cardiovascular disease (ASCVD). This article reviews why LDL-C remains overlooked and underestimated despite numerous studies that have proved its role.Recently published EAS/ESC Guidelines for dyslipidemia and EAS Guidelines for prevention set new targets for LDL-C levels in primary and secondary prevention of ASCVD. These guidelines are based on data from large studies and meta-analyzes that have shown that lower LDL-C also means lower cardiovascular event rates. Real-life experience published in registries worldwide has shown us that the guidelines have not been translated to everyday clinical practice, meaning that a significant number of patients are undertreated and have LDL-C levels well above target. Potential reasons for the abovementioned are poor adherence and education of the patient and physician and health care system related factors. Implementation of the latest version of guidelines will require continuous patient and physicians education, as well as a shared decision-making process between physician and patient.