Biofilms represent the dominant mode of bacterial existence in natural and man-made environments. Bacteria within biofilms possess collective biofilm-imposed properties that make them distinct from their planktonic counterparts. One key property is an enhanced resistance to antimicrobials. Previous strategies to treat biofilms have focused on either single or combined chemical treatments or physical removal. Considering that many chronic bacterial illnesses are associated with multispecies biofilms, such approaches may not be effective because juxtaposed species can act synergistically to enhance recalcitrance to treatments, resulting in treatment failure. This section will introduce the reader to the processes leading to the development of human-associated polymicrobial biofilms with a particular emphasis on multispecies succession, ecology, and integration by pathogenic bacteria. Then, cognizant of processes and properties, newly developed or promising approaches to control pathogenic biofilm communities will be considered. These approaches will either be preventative or therapeutic and based upon the manipulation of biological processes (e.g., cell–cell signaling, coaggregation, treatment with phage) or based purely upon technological advances (e.g., cold plasma, modified-surface technologies, nanoparticles). The advantages and disadvantages of the different approaches will be discussed and future prospects considered. Recognizing the current issues associated with the spread of antimicrobial resistance and the overall recalcitrance of biofilms, we propose that new technologies to prevent disease or approaches to craft communities to maintain health should be a mainstay of current biofilm research.