Nanoscale Metal-Organic Layers for Deeply Penetrating X-ray-Induced Photodynamic Therapy
- Resource Type
- Authors
- Kaiyuan Ni; Guangxu Lan; Ruoyu Xu; Christina Chan; Wenbin Lin; Kuangda Lu; Zekai Lin
- Source
- Angewandte Chemie International Edition. 56:12102-12106
- Subject
- medicine.medical_treatment
Antineoplastic Agents
Photodynamic therapy
02 engineering and technology
Microscopy, Atomic Force
010402 general chemistry
Photochemistry
01 natural sciences
Tricarboxylate
Article
Catalysis
Metal
Mice
Bipyridine
chemistry.chemical_compound
Microscopy, Electron, Transmission
medicine
Animals
Nanotechnology
SBus
Metal-Organic Frameworks
Photosensitizing Agents
Fourier Analysis
Chemistry
X-Rays
X-ray
Rational design
General Medicine
General Chemistry
021001 nanoscience & nanotechnology
Xenograft Model Antitumor Assays
0104 chemical sciences
Photochemotherapy
visual_art
Colonic Neoplasms
visual_art.visual_art_medium
Ruthenium Compounds
Metal-organic framework
Reactive Oxygen Species
0210 nano-technology
Powder Diffraction
- Language
- ISSN
- 1433-7851
We report the rational design of metal-organic layers (MOLs) that are built from [Hf6 O4 (OH)4 (HCO2 )6 ] secondary building units (SBUs) and Ir[bpy(ppy)2 ]+ - or [Ru(bpy)3 ]2+ -derived tricarboxylate ligands (Hf-BPY-Ir or Hf-BPY-Ru; bpy=2,2'-bipyridine, ppy=2-phenylpyridine) and their applications in X-ray-induced photodynamic therapy (X-PDT) of colon cancer. Heavy Hf atoms in the SBUs efficiently absorb X-rays and transfer energy to Ir[bpy(ppy)2 ]+ or [Ru(bpy)3 ]2+ moieties to induce PDT by generating reactive oxygen species (ROS). The ability of X-rays to penetrate deeply into tissue and efficient ROS diffusion through ultrathin 2D MOLs (ca. 1.2 nm) enable highly effective X-PDT to afford superb anticancer efficacy.