The “PeRsOnalized Prevention roadmap for the future HEalThcare” (PROPHET) project, funded by the European Union’s Horizon Europe research and innovation program and linked to ICPerMed, seeks to develop a Strategy Research and Innovation Agenda (SRIA) for the European Union. Find attached the protocol that corresponds to one of the first steps in the PROPHET, namely a review that aims to map the evidence and highlight the evidence gaps in research or use of biomarkers in personalized prevention in the general population, as well as their integration with digital technologies.