Early human brain development : insights into macroscale connectome wiring
- Resource Type
- Authors
- Ruben Schmidt; Linda S. de Vries; Siemon C. de Lange; Manon J.N.L. Benders; Martijn P. van den Heuvel; Kristin Keunen; Pim Moeskops; Lisanne J. Stolwijk; Ivana Išgum; Hannelore K. van der Burgh; Marcel A. de Reus
- Source
- Pediatric Research, 84, 829. Lippincott Williams and Wilkins
Keunen, K, van der Burgh, H K, de Reus, M A, Schmidt, R, de Lange, S C, de Vries, L S, Benders, M J & van den Heuvel, M P 2018, ' Early human brain development : insights into macroscale connectome wiring ', Pediatric Research, vol. 84, no. 6, pp. 829-836 . https://doi.org/10.1038/s41390-018-0138-1
Pediatric research, 84(6), 829-836. Lippincott Williams and Wilkins
Pediatric Research, 84(6), 829-836. Lippincott Williams and Wilkins
Keunen, K, van der Burgh, H K, de Reus, M A, Moeskops, P, Schmidt, R, Stolwijk, L J, de Lange, S C, Išgum, I, de Vries, L S, Benders, M J & van den Heuvel, M P 2018, ' Early human brain development : insights into macroscale connectome wiring ', Pediatric Research, vol. 84, no. 6, pp. 829-836 . https://doi.org/10.1038/s41390-018-0138-1
- Subject
- 0301 basic medicine
Adult
Male
SDG 16 - Peace
Brain development
Neuroimaging
Biology
White matter
03 medical and health sciences
Young Adult
0302 clinical medicine
Fractional anisotropy
medicine
Connectome
Humans
Gray Matter
Child
Preschool
Premature
Myelin Sheath
Myelin Sheath/metabolism
Gray Matter/diagnostic imaging
White Matter/diagnostic imaging
SDG 16 - Peace, Justice and Strong Institutions
Infant, Newborn
Infant
Human brain
Newborn
White Matter
Justice and Strong Institutions
Neuroanatomy
030104 developmental biology
medicine.anatomical_structure
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Child, Preschool
Pediatrics, Perinatology and Child Health
Anisotropy
Female
Neuroscience
030217 neurology & neurosurgery
Infant, Premature
Diffusion MRI
- Language
- English
- ISSN
- 0031-3998
BACKGROUND: Early brain development is closely dictated by distinct neurobiological principles. Here, we aimed to map early trajectories of structural brain wiring in the neonatal brain.METHODS: We investigated structural connectome development in 44 newborns, including 23 preterm infants and 21 full-term neonates scanned between 29 and 45 postmenstrual weeks. Diffusion-weighted imaging data were combined with cortical segmentations derived from T2 data to construct neonatal connectome maps.RESULTS: Projection fibers interconnecting primary cortices and deep gray matter structures were noted to mature faster than connections between higher-order association cortices (fractional anisotropy (FA) F = 58.9, p CONCLUSION: Employing postnatal neuroimaging we reveal that early maturational trajectories of white matter pathways display discriminative developmental features of the neonatal brain network. These findings provide valuable insight into the early stages of structural connectome development.