Recent progress in the identification of adenosine monophosphate-activated protein kinase (AMPK) activators
- Resource Type
- Authors
- Kimberly O. Cameron; Ravi G. Kurumbail
- Source
- Bioorganic & Medicinal Chemistry Letters. 26:5139-5148
- Subject
- 0301 basic medicine
Adenosine monophosphate
Protein Conformation
Clinical Biochemistry
Enzyme Activators
Pharmaceutical Science
mTORC1
AMP-Activated Protein Kinases
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
AMP-activated protein kinase
Heterotrimeric G protein
Drug Discovery
medicine
Animals
Humans
Phosphorylation
Protein kinase A
Molecular Biology
biology
Chemistry
Organic Chemistry
AMPK
Adenosine
Cell biology
Enzyme Activation
030104 developmental biology
biology.protein
Molecular Medicine
GLUT4
medicine.drug
- Language
- ISSN
- 0960-894X
Adenosine monophosphate-activated protein kinase (AMPK), a serine/threonine heterotrimeric protein kinase, is a critical regulator of cellular and whole body energy homeostasis. There are twelve known AMPK isoforms that are differentially expressed in tissues and species. Dysregulation of AMPK signaling is associated with a multitude of human pathologies. Hence isoform-selective activators of AMPK are actively being sought for the treatment of cardiovascular and metabolic diseases. The present review summarizes the status of direct AMPK activators from the patent and published literature.