Additional file 1 of KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells
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- Mathison, Angela J.; Kerketta, Romica; de Assuncao, Thiago Milech; Leverence, Elise; Zeighami, Atefeh; Urrutia, Guillermo; Stodola, Timothy J.; di Magliano, Marina Pasca; Iovanna, Juan L.; Zimmermann, Michael T.; Lomberk, Gwen; Urrutia, Raul
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Additional file 1: Fig S1. Induction of KrasG12D leads to changes in global histone mark levels. Fig S2. Induction of KrasG12D leads to changes in phosphorylation events. Fig S3. Induction of KrasG12D leads to changes in the remodeling of activating chromatin. Fig S4. Annotation of DMCs with non-repeats and repetitive elements. Fig S5. Ingenuity Pathway Analysis (IPA) of RNA-seq genes. Fig S6. Gene enrichment analysis of RNA-seq genes. Fig S7. Upstream regulatory analysis of RNA-seq genes conducted in IPA. Fig S8. RNA-seq analysis following oncogenic KrasG12D induction in 1012 and 9085 cell lines. Fig S9. Chromatin marks at gene bodies for up and downregulated transcripts following KrasG12D induction. Fig S10. Networks generated from genes associated with H3K27ac, H3K4me3 and H3K36me3 marks, enlarged figure with gene details of Fig. 9i from the main manuscript. Fig S11. Uncropped version of western blots present in Fig. 1b of the main manuscript. Fig S12. Uncropped version of western blots present in Supplementary Figure 1. Fig S13. Uncropped version of western blots present in Supplementary Figure 2.