Aim It is well established that (i) magnetic resonance imaging (MRI), (ii) Multidisciplinary Cancer Conference (MCC), (iii) pre-operative radiotherapy, (iv) Total Mesorectal Excision (TME) surgery and (v) pathologic assessment as described by Quirke are key processes necessary for high quality, rectal cancer care. The objective was to select a set of multidisciplinary, quality indicators to measure the uptake of these clinical processes in clinical practice. Method A multidisciplinary panel was convened and a modified, two phase Delphi method was used to select a set of quality indicators. Phase 1 included a literature review with written feedback from the panel. Phase 2 included an in-person workshop with anonymous voting. The selection criteria for the indicators were: strength of evidence, ease of capture and usability. Indicators for which ≥90% of the panel members voted "to keep" were selected as the final set of indicators. Results During Phase 1, 68 potential indicators were generated from the literature and an additional 5 indicators were recommended by the panel. During Phase 2, these 73 indicators were discussed and 48 indicators met the 90% inclusion threshold and included 8 pathology, 5 radiology, 11 surgical, 6 radiation oncology and 18 MCC indicators. Conclusion A modified Delphi method was used to select 48 multidisciplinary, quality indicators to specifically measure the uptake of key processes necessary for high quality care of patients with rectal cancer. These quality indicators will be used in future work to identify and address gaps in care in the uptake of these clinical processes.