Genes of intestinal Escherichia coli and their relation to the inflammatory activity in patients with ulcerative colitis and Crohn’s disease
- Resource Type
- Authors
- L. Siegfried; I. Lazurova; Marta Kmeťová; L. Gombosova; Katarína Čurová; D. Petrasova; Maria Zakuciova
- Source
- Folia Microbiologica
- Subject
- Adult
Male
Biology
medicine.disease_cause
Polymerase Chain Reaction
Microbiology
Article
Crohn Disease
Escherichia coli
medicine
Humans
Interleukin 8
Colitis
Interleukin 6
Escherichia coli Infections
Aged
Czech Republic
Inflammation
Crohn's disease
Interleukin-6
Tumor Necrosis Factor-alpha
Interleukin-8
Interleukin
General Medicine
Middle Aged
biochemical phenomena, metabolism, and nutrition
medicine.disease
Ulcerative colitis
digestive system diseases
Anti-Bacterial Agents
Bacterial Typing Techniques
Interleukin-10
Intestines
Interleukin 10
Case-Control Studies
Immunology
biology.protein
bacteria
Colitis, Ulcerative
Female
Fimbriae Proteins
- Language
- ISSN
- 1874-9356
0015-5632
Escherichia coli gene fimA was the most frequent gene that occurred in the intestine of all investigated groups. All subjects with fimA gene had significantly higher values of tumor necrosis factor alpha (TNF-α) and CRP than those with other E. coli genes. There was also a tendency to increased serum interleukin (IL)-6 levels in patients carrying the fimA gene; however, no relation was observed to serum IL-8 and IL-10. Patients with Crohn's disease had significantly higher IL-6 than those with ulcerative colitis (UC) and controls. The highest levels of TNF-α were detected in the UC group. There were no significant differences in serum IL-8 and IL-10 between all three groups. The presence of E. coli gene fimA in the large bowel of patients with IBD is related to the immunological activity of the disease which may be important from the aspect of therapeutical strategy.