This paper reports on important unexplored medicinal plants growing near water bodies from Bonaigarh, Sundargarh district of Odisha that can be used to treat and cure a number of ailments. Data were collected through series of questionnaire with elderly people residing in that regions. A list of 30 unexplored plant species along with their botanical names, local names, family, parts used and medicinal uses has been discussed. Most of the plant species from this region belong to the family Acanthaceae, Polygonaceae and Moraceae. Different parts of these unexplored plants such as fruits, roots, leaves, bark are used to treat and cure different human disorders and diseases. Thus there is a need to carry out the study on medicinal values of plants growing near water bodies.