Neurocognitive Phenotyping: Identifying Markers of Current and Future Mood Symptoms
- Resource Type
- Authors
- Kaiser, Roselinde
- Source
- Subject
- Medicine and Health Sciences
Psychiatry and Psychology
- Language
Mood disorders are a leading cause of disability and mortality worldwide. Efforts to understand the nature of mood disorders have been hampered by high levels of heterogeneity within diagnostic categories and comorbidity across diagnoses. One strategy for addressing such challenges is to conceptualize mood disorders according to clusters of cognitive and neurobiological abnormality or neurocognitive phenotypes that can be objectively measured. Key domains of cognitive dysfunction that have been observed in mood disorders are deficits in goal-directed behavior (executive functioning (EF)), and abnormalities in reward processing that are related to excessively blunted or amplified sensitivity to rewards (reward sensitivity (RS). Among patients, identifying abnormalities in these neurocognitive domains may provide useful insight into the mechanisms of specific types of mood symptoms, and may help to predict the future course of mood symptoms in daily life. This study is supported by a NARSAD Young Investigator Award to R. Kaiser (2016). Aims 1-2 were proposed in the original application. Aims 3-4 were added at the time of initiating recruitment.