Fractures of thoracic vertebrae in patients with locally advanced non-small cell lung carcinoma treated with intensity modulated radiotherapy
- Resource Type
- Authors
- José Belderbos; Chun Chen; Josien de Bois; Michel M. van den Heuvel; Charlotte A.H. Lange; Wilma Uyterlinde; Jan-Jakob Sonke
- Source
- Radiotherapy and Oncology. 118:437-441
- Subject
- Adult
Male
medicine.medical_specialty
Lung Neoplasms
Thoracic Vertebrae
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Median follow-up
Carcinoma, Non-Small-Cell Lung
medicine
Carcinoma
Humans
Radiology, Nuclear Medicine and imaging
Aged
Retrospective Studies
Aged, 80 and over
Lung
business.industry
Incidence (epidemiology)
Case-control study
Retrospective cohort study
Hematology
Middle Aged
medicine.disease
Small Cell Lung Carcinoma
Fractures, Spontaneous
medicine.anatomical_structure
Oncology
Case-Control Studies
030220 oncology & carcinogenesis
Thoracic vertebrae
Spinal Fractures
Female
Radiotherapy, Intensity-Modulated
Radiology
business
- Language
- ISSN
- 0167-8140
To report on the incidence of vertebral fractures in patients treated with Intensity Modulated Radiotherapy (IMRT) for locally advanced non-small cell lung carcinoma (NSCLC) and to analyse the association with clinical and dosimetric parameters.Between 2007 and 2012, 524 patients treated with ⩾51 Gy were retrospectively analysed for the incidence of vertebral fractures (VF). Clinical parameters were assessed. In addition, a case control study in 50 patients was performed to study the association between the radiotherapy dose and fractured vertebrae.Three hundred and thirty-six patients were eligible for analyses. Twenty-eight patients (8%) were observed with VF at a median follow up of 12 months. Age was significantly higher in the group with VF (p0.01). After balancing age, the mean vertebrae dose was most significantly associated with fractures of the vertebrae (p0.01).VF was observed in 8% of the patients with locally advanced NSCLC. RT dose was associated with the occurrence of thoracic vertebral fractures.