Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR
- Resource Type
- Source
- Bioorganicmedicinal chemistry letters. 17(8)
- Subject
Quantitative structure–activity relationship Stereochemistry Clinical Biochemistry Anti-Inflammatory Agents Pharmaceutical Science Crystallographic data Quantitative Structure-Activity Relationship Biochemistry Chemical synthesis Rats, Sprague-Dawley chemistry.chemical_compound Inhibitory Concentration 50 Drug Discovery Inhibitory concentration 50 Animals Humans Pharmacokinetics Lymphocytes Bifunctional Molecular Biology Protein Kinase Inhibitors Chemistry Organic Chemistry Rats Sprague dawley Pyrimidines Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Molecular Medicine Interleukin-2 Lymphocyte Culture Test, Mixed Selectivity - Language
- ISSN
- 0960-894X