PURPOSE: To present a reproducible methodology for building an anatomy mimicking phantom with targeted T(1) and T(2) contrast for use in quantitative magnetic resonance imaging. METHODS: We propose a reproducible method for creating high-resolution, quantitative slice phantoms. The phantoms are created using gels with different concentrations of NiCl(2) and MnCl(2) to achieve targeted T(1) and T(2) values. We describe a calibration method for accurately targeting anatomically realistic relaxation pairs. In addition, we developed a method of fabricating slice phantoms by extruding 3D printed walls on acrylic sheets. These procedures are combined to create a physical analog of the Brainweb digital phantom. RESULTS: With our method, we are able to target specific T(1)/T(2) values with less than 10% error. Additionally, our slice phantoms look realistic since their geometries are derived from anatomical data. CONCLUSION: Standardized and accurate tools for validating new techniques across sequences, platforms, and different imaging sites are important. Anatomy mimicking, multi-contrast phantoms designed with our procedures could be used for evaluating, testing, and verifying model-based methods.