Palladium-Catalyzed Amidation and Amination of (Hetero)aryl Chlorides under Homogeneous Conditions Enabled by a Soluble DBU/NaTFA Dual-Base System
- Resource Type
- Authors
- Steven R. Wisniewski; Gregory L. Beutner; Eric M. Simmons; Rebecca A. Green; Bahar Inankur; Frederick Roberts; John R. Coombs; Dong Lin; Jun Qiu
- Source
- Organic Process Research & Development. 23:1529-1537
- Subject
- inorganic chemicals
chemistry.chemical_classification
Reaction conditions
Base (chemistry)
010405 organic chemistry
Aryl
Organic Chemistry
chemistry.chemical_element
010402 general chemistry
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Catalysis
chemistry.chemical_compound
chemistry
Homogeneous
Physical and Theoretical Chemistry
Amination
Palladium
- Language
- ISSN
- 1520-586X
1083-6160
The palladium-catalyzed coupling of aryl and heteroaryl chlorides with primary amides under mild homogeneous reaction conditions is reported. Successful C–N coupling is enabled by the use of a uniq...