Iterative Synthesis of Oligo[ n ]rotaxanes in Excellent Yield
- Resource Type
- Authors
- Luca Cera; Joby Winn; James E. M. Lewis; Stephen M. Goldup
- Source
- Journal of the American Chemical Society
- Subject
- ANION-BINDING
ALPHA-CYCLODEXTRIN
Stereochemistry
Chemistry, Multidisciplinary
INSULATED MOLECULAR WIRES
SUPRAMOLECULAR HYDROGELS
010402 general chemistry
01 natural sciences
Biochemistry
Catalysis
Colloid and Surface Chemistry
Molecule
OXIDE) TRIBLOCK COPOLYMERS
ONE-POT
Science & Technology
010405 organic chemistry
Chemistry
ACTIVE-TEMPLATE SYNTHESIS
General Chemistry
Combinatorial chemistry
3. Good health
0104 chemical sciences
INDUCED LOCALIZATION
ANION-BINDING CATALYSIS
BLOCK-SELECTED INCLUSION
HOST-GUEST
Yield (chemistry)
Physical Sciences
METAL TEMPLATE SYNTHESIS
SOLID-PHASE
CLICK CHEMISTRY
03 Chemical Sciences
AZIDE-ALKYNE CYCLOADDITION
- Language
- ISSN
- 0002-7863
We present an operationally simple iterative coupling strategy for the synthesis of oligomeric homo- and hetero-[n]rotaxanes with precise control over the position of each macrocycle. The exceptional yield of the AT-CuAAC reaction, combined with optimized conditions that allow the rapid synthesis of the target oligomers, opens the door to the study of precision-engineered oligomeric interlocked molecules.