Hong Kong Special Administrative Region (SAR), China and Singapore are both facing considerable Omicron variant epidemic. However, the overwhelmed medical system and high case fatality ratio (CFR) just occurred in Hong Kong SAR, China but not in Singapore.The low vaccination coverage in Hong Kong SAR, China, especially among the older adults, is shown to be a primary reason of its recent high CFR.Facing the potential epidemic risk, non-vaccinated, non-fully-vaccinated, and non-booster-vaccinated people in China, especially the elderly, should get any type of accessible vaccine, which could save lives when the infection unfortunately befalls.