Local D2- to D1-neuron transmodulation updates goal-directed learning in the striatum
- Resource Type
- Authors
- Stuart B. Mazzone; Alice E McGovern; Bernard W. Balleine; Miriam Matamales; Jesus Bertran-Gonzalez; Jia Dai Mi
- Source
- Science. 367:549-555
- Subject
- Male
Activation markers
Striatum
Medium spiny neuron
Mice
03 medical and health sciences
0302 clinical medicine
Dopamine
Dopamine receptor D2
medicine
Animals
Learning
030304 developmental biology
Raclopride
0303 health sciences
Multidisciplinary
Receptors, Dopamine D2
Dopaminergic Neurons
Receptors, Dopamine D1
Corpus Striatum
Nucleosomes
Mice, Inbred C57BL
medicine.anatomical_structure
Dopamine receptor
Dopamine Antagonists
Female
Neuron
Goals
Neuroscience
030217 neurology & neurosurgery
medicine.drug
- Language
- ISSN
- 1095-9203
0036-8075
A learning mechanism in the striatum An intriguing characteristic of the striatum is the random spatial distribution and high degree of intermingling between expression of dopamine receptor types 1 (D1) and 2 (D2) within striatal projection neurons (SPNs). The resulting highly entropic mosaic extends through a homogeneous space and is mostly devoid of histological boundaries. The rules established locally by D1- and D2-expressing SPNs (D1-SPNs and D2-SPNs) are thus likely critical in defining how functional territories develop throughout the striatum. Matamales et al. found that activated D2-SPNs access and modify developing behavioral programs encoded by regionally defined ensembles of transcriptionally active D1-SPNs. This process is slow because it depends on the molecular integration of additive neuro-modulatory signals. However, with time, it creates the regional functional boundaries that are necessary to identify and shape specific learning in the striatum. Science , this issue p. 549