Untargeted mass spectrometric approach in metabolic healthy offspring of patients with type 2 diabetes reveals medium-chain acylcarnitine as potential biomarker for lipid induced glucose intolerance (LGIT)
- Resource Type
- Authors
- Jorg Kotzka; Jens Fuchser; Simone Lange; Susanne Mack; Dirk Müller-Wieland; Gabriela Zurek; Martina Schiller; Stefan Lehr; Aiko Barsch; Birgit Knebel; J Haas
- Source
- Archives of physiology and biochemistry. 122(5)
- Subject
- 0301 basic medicine
Proband
Adult
Blood Glucose
Male
medicine.medical_specialty
Adolescent
Physiology
Offspring
Metabolite
030209 endocrinology & metabolism
Type 2 diabetes
Biology
Mass Spectrometry
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Physiology (medical)
Diabetes mellitus
Internal medicine
Carnitine
Glucose Intolerance
Genetic predisposition
medicine
Metabolome
Humans
Aged
General Medicine
Glucose Tolerance Test
Middle Aged
medicine.disease
Lipids
030104 developmental biology
Endocrinology
Postprandial
chemistry
Diabetes Mellitus, Type 2
Case-Control Studies
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Female
Biomarkers
Chromatography, Liquid
- Language
- ISSN
- 1744-4160
Offspring of type 2 diabetes (T2D) patients have increased risk to develop diabetes, due to inherited genetic susceptibility that directly interferes with the individual adaption to environmental conditions. We characterise T2D offspring (OSP) to identify metabolic risk markers for early disease prediction. Plasma of metabolically healthy OSP individuals (n = 43) was investigated after an oral lipid tolerance test (oLTT) by an untargeted mass spectrometric approach for holistic metabolome analyses. Two subgroups of OSP probands can be separated by oLTT, although not differing in general clinical parameters. Analyses of the plasma metabolome revealed mainly medium-chain acylcarnitines and very long-chain fatty acids with differential abundance in the subgroups. The study presented indicates that metabolically healthy OSP of T2D patients differ upon metabolic challenging in serum metabolite composition, especially medium-chain acylcarnitines. The difference suggest that postprandial lipid induced glucose intolerance (LGIT) may serve as a further valuable marker for early diabetes prediction.