Methylphenidate modifies reward cue responses in adults with ADHD: An fMRI study
- Resource Type
- Authors
- Paulo Mattos; Myriam Monteiro; Jorge Moll; Emi Furukawa; Patricia Bado; Jeff Wickens; Sebastian Hoefle; Raquel Quimas Molina da Costa; Gail Tripp; Paula Vigne
- Source
- Neuropharmacology. 162:107833
- Subject
- Adult
Male
0301 basic medicine
Conditioning, Classical
Prefrontal Cortex
Striatum
Placebo
behavioral disciplines and activities
Placebos
Young Adult
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Dopamine Uptake Inhibitors
Double-Blind Method
Reward
mental disorders
medicine
Humans
Attention deficit hyperactivity disorder
Prefrontal cortex
Pharmacology
medicine.diagnostic_test
Methylphenidate
Functional Neuroimaging
Ventral striatum
Classical conditioning
medicine.disease
Magnetic Resonance Imaging
Neostriatum
030104 developmental biology
medicine.anatomical_structure
Attention Deficit Disorder with Hyperactivity
Case-Control Studies
Ventral Striatum
Female
Cues
Psychology
Functional magnetic resonance imaging
Neuroscience
psychological phenomena and processes
030217 neurology & neurosurgery
medicine.drug
- Language
- ISSN
- 0028-3908
Attention deficit hyperactivity disorder (ADHD) has been associated with neural hyposensitivity to reward-predicting cues. Methylphenidate is widely used in the management of the disorder's symptoms, but its effects on reward sensitivity in ADHD are unknown. The current study used fMRI to measure striatal responses to reward-predicting cues in adults with ADHD on and off methylphenidate and a control group, during a classical conditioning task. Responses to cued reward were also explored. Larger differences in the ventral striatum activation to reward cues versus non-reward cues were observed when the ADHD participants were on methylphenidate compared to placebo. In response to cued-reward outcome, an exploratory analysis showed methylphenidate reduced the BOLD time-series correlation between the dorsal striatum and dorsal medial prefrontal cortex. Methylphenidate's therapeutic effects may be mediated by altering reward processing in individuals with ADHD.