Pressure-Flow Experimental Performance of New Intravascular Blood Pump Designs for Fontan Patients
- Resource Type
- Authors
- Amy L. Throckmorton; Carson S. Fox; John T. Rozolis; Michelle L. Riddle; Kelli L. McKenna; Jay P. Patel; Steven G. Chopski
- Source
- Artificial Organs. 40:233-242
- Subject
- Materials science
Axial-flow pump
Adult patients
Flow (psychology)
Biomedical Engineering
Medicine (miscellaneous)
Bioengineering
General Medicine
030204 cardiovascular system & hematology
Fontan physiology
Biomaterials
Blood pump
03 medical and health sciences
Impeller
0302 clinical medicine
030228 respiratory system
Single ventricle physiology
Biomedical engineering
- Language
- ISSN
- 0160-564X
An intravascular axial flow pump is being developed as a mechanical cavopulmonary assist device for adolescent and adult patients with dysfunctional Fontan physiology. Coupling computational modeling with experimental evaluation of prototypic designs, this study examined the hydraulic performance of 11 impeller prototypes with blade stagger or twist angles varying from 100 to 600 degrees. A refined range of twisted blade angles between 300 and 400 degrees with 20-degree increments was then selected, and four additional geometries were constructed and hydraulically evaluated. The prototypes met performance expectations and produced 3-31 mm Hg for flow rates of 1-5 L/min for 6000-8000 rpm. A regression analysis was completed with all characteristic coefficients contributing significantly (P < 0.0001). This analysis revealed that the impeller with 400 degrees of blade twist outperformed the other designs. The findings of the numerical model for 300-degree twisted case and the experimental results deviated within approximately 20%. In an effort to simplify the impeller geometry, this work advanced the design of this intravascular cavopulmonary assist device closer to preclinical animal testing.