Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study
- Resource Type
- Authors
- Janja Jazbar; Mitja Kos; Nanca Cebron Lipovec
- Source
- Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
- Subject
- Adult
Male
Pediatrics
medicine.medical_specialty
Adolescent
Databases, Factual
medicine.drug_class
Cross-sectional study
Urinary system
Population
Slovenia
MEDLINE
lcsh:Medicine
030204 cardiovascular system & hematology
Cholinergic Antagonists
Article
03 medical and health sciences
Young Adult
0302 clinical medicine
Medical research
Anticholinergic
Medicine
Humans
030212 general & internal medicine
Medical prescription
Young adult
lcsh:Science
education
Child
Aged
education.field_of_study
Multidisciplinary
business.industry
lcsh:R
Nationwide database
Health care
Cross-Sectional Studies
Risk factors
lcsh:Q
Female
business
- Language
- ISSN
- 2045-2322
Anticholinergic burden has been widely studied in specific patient populations with specific conditions. However, the prevalence in the general population is poorly understood. This retrospective cross-sectional study was a nationwide database analysis of outpatient prescriptions of anticholinergic medications. The study was based on Slovenian health claims data of all outpatient prescriptions in 2018. Anticholinergic burden was evaluated using the Anticholinergic Cognitive Burden scale. Three age groups were analysed: children (≤18 years), adults (19–64 years) and older adults (≥65 years). Anticholinergic medications were prescribed to 29.8% of the participants; 7.6% were exposed to a clinically significant anticholinergic burden. The proportion of patients exposed to anticholinergic burden was highest in older adults (43.2%), followed by adults (25.8%) and children (20.7%). The most frequently prescribed medications with the highest anticholinergic activity were antipsychotics and medications for urinary diseases (42.8% and 40.2%, respectively). Medications with second highest activity were mostly antiepileptics (87.3%). Medications with possible anticholinergic activity included diverse therapeutic groups. Anticholinergic burden is highest in older adults but is also considerable among adults and children. Medications with anticholinergic activity belong to diverse therapeutic groups. Further research is needed on safe use of these medications in all age groups.