A case of ovarian endometrioid adenocarcinoma with yolk sac differentiation and Lynch syndrome
- Resource Type
- Authors
- Kathy Kenley; Lauren S. Krill; B. Levin; Janhvi Sookram; Julieta Barroeta; Pallav Mehta
- Source
- Gynecologic Oncology Reports
Gynecologic Oncology Reports, Vol 27, Iss, Pp 60-64 (2019)
- Subject
- medicine.medical_specialty
Yolk sac tumor
endocrine system diseases
Ovarian endometrioid adenocarcinoma
lcsh:Gynecology and obstetrics
lcsh:RC254-282
Germline
03 medical and health sciences
0302 clinical medicine
Ovarian cancer
medicine
Germ cell tumor
Case Series
Yolk sac
neoplasms
lcsh:RG1-991
Genetic testing
Gynecology
Mixed tumor
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
business.industry
Obstetrics and Gynecology
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Lynch syndrome
digestive system diseases
female genital diseases and pregnancy complications
Young age
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
embryonic structures
business
- Language
- English
- ISSN
- 2352-5789
Ovarian endometrioid adenocarcinoma with yolk sac component has been reported in fewer than twenty cases in the literature. A majority of the diagnoses are described in postmenopausal women without specific reference to germline genetic testing. We describe, to our knowledge, the first case in the English literature of a premenopausal woman that presented with an ovarian endometrioid adenocarcinoma with focal yolk sac component and was subsequently found to have a germline MSH2 mutation confirming a diagnosis of Lynch syndrome. Concurrent diagnosis of ovarian endometrioid adenocarcinoma with yolk sac tumor and Lynch syndrome is an extremely rare finding in a young patient and requires careful follow-up. Genetics evaluation and testing may be reasonable for individuals with this rare or mixed tumor pathology at young age of onset and can have clinical utility in guiding future cancer treatment or surveillance.
Highlights • Ovarian endometrioid adenocarcinoma with associated yolk sac tumor is a rare entity. • A thorough histological and immunohistochemical assessment is required to reach an accurate diagnosis. • Genetics evaluation for Lynch syndrome may be reasonable for rare ovarian tumors.