Heartburn as a Marker of the Success of Acid Suppression Therapy in Chronic Cough
- Resource Type
- Authors
- Vikas Bansal; Anupong Tangaroonsanti; Huda Badri; Imran Satia; Augustine S. Lee; Lesley A. Houghton; Kenneth R. DeVault; Muhammad Asif Mangi; Jacky Smith
- Source
- Lung
Badri, H, Satia, I, Bansal, V, Mangi, A, Tangaroonsanti, KR, Devault, K, Lee, A, Houghton, L & Smith, J 2021, ' Heartburn as a marker of the success of acid suppression therapy in chronic cough ', Lung . https://doi.org/10.1007/s00408-021-00496-w
- Subject
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Gastroesophageal Reflux-Associated Chronic Cough
Acid suppression
Disease
Logistic regression
Heartburn
Gastro-oesophageal reflux disease
Internal medicine
Chronic cough
medicine
Humans
Retrospective Studies
Response rate (survey)
business.industry
Reflux
Middle Aged
Response to treatment
Cough
Chronic Disease
Gastroesophageal Reflux
Female
medicine.symptom
business
- Language
- ISSN
- 1432-1750
Purpose Gastro-oesophageal reflux disease (GORD) is commonly thought to play an important role in chronic cough and patients are often empirically treated with acid suppression therapy. We sought to investigate the response rate to acid suppression treatment in patients with and without heartburn attending two specialist cough clinics. Methods A retrospective review of 558 consecutive patients referred to two specialist cough clinics was performed (UK and USA). Patients who were treated with acid suppression were included and their documented response to treatment was collected. Binary logistic regression was used to ascertain the value of reported heartburn in predicting the response of chronic cough to acid suppression therapy. Results Of 558 consecutive referrals, 238 patients were excluded due to missing data or cough duration of Conclusion In specialist cough clinics, few patients report a response of their chronic cough to acid suppression therapy. Nonetheless, heartburn is a useful predictor substantially increasing the likelihood of benefit.