A Low-Incidence Red Cell Antigen JAL Associated with Two Unusual Rh Gene Complexes
- Resource Type
- Authors
- K. Kirkley; C.A. Green; J. McCreary; J. Poole; H. Hustinx; G.S. Nicholson; Marilyn Moulds; M. Redman; N. Salaru; C. Lomas
- Source
- Vox Sanguinis. 59:39-43
- Subject
- Male
Isoantigens
Rh-Hr Blood-Group System
biology
Red Cell
Locus (genetics)
Hematology
General Medicine
Molecular biology
Gene product
Red blood cell
medicine.anatomical_structure
Antigen
Isoantibodies
medicine
biology.protein
Humans
Multicenter Studies as Topic
Female
Antibody
Gene
Rh blood group system
- Language
- ISSN
- 1423-0410
0042-9007
A multilaboratory investigation during several years has identified a low incidence antigen JAL on the red cells of 7 propositi. JAL appears to be associated with two unusual Rh complexes, one of which produces a depressed C antigen and the other a depressed c antigen. Family studies strongly suggest that the JAL antigen is encoded by the RH locus. Anti-JAL has been implicated in haemolytic disease of the newborn and is thus considered to be a clinically significant antibody.