Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain
- Resource Type
- Authors
- G. Guilbaud; V. Kayser; J. A. Desmeules
- Source
- Pain, Vol. 53, No 3 (1993) pp. 277-285
- Subject
- Male
Pyrrolidines
Narcotic Antagonists
Receptors, Opioid, delta/drug effects
Receptors, Opioid, mu
Benzeneacetamides
(+)-Naloxone
Naltrexone
Receptors, Opioid, mu/drug effects
Rats, Sprague-Dawley
chemistry.chemical_compound
Opioid receptor
Receptors, Opioid, delta
Drug Interactions
Narcotic Antagonists/pharmacology
Receptors, Opioid, kappa/drug effects
Pain Measurement
Analgesics
ddc:615
ddc:617
Naloxone
Enkephalins
Benzomorphans
DAMGO
Nociception
Neurology
Neuropathic pain
Analgesics/therapeutic use
Enkephalins/therapeutic use
Oligopeptides
medicine.drug
Pain Threshold
medicine.medical_specialty
medicine.drug_class
Pain Threshold/drug effects
Receptors, Opioid/drug effects
Pain
Naltrindole
Naloxone/pharmacology
Pain/drug therapy
Internal medicine
medicine
Animals
business.industry
Receptors, Opioid, kappa
Naltrexone/analogs & derivatives/pharmacology
Enkephalin, Ala(2)-MePhe(4)-Gly(5)
Rats
Vocalization, Animal/drug effects
Disease Models, Animal
Pyrrolidines/therapeutic use
Anesthesiology and Pain Medicine
Endocrinology
Benzomorphans/pharmacology
chemistry
Opioid
Receptors, Opioid
Oligopeptides/therapeutic use
Neurology (clinical)
Vocalization, Animal
business
Pain Measurement/drug effects
- Language
- English
- ISSN
- 0304-3959
This study evaluated the antinociceptive effects of systemically administered selective opioid agonists of mu (DAMGO), delta (BUBU) and kappa (U 69593) receptors on the vocalization threshold to paw pressure in a rat model of peripheral unilateral mononeuropathy produced by loose ligatures around the common sciatic nerve. DAMGO (0.5-2 mg/kg), BUBU (1.5-6 mg/kg) and U 69593 (0.75-3 mg/kg) injected intravenously (i.v.) produced a potent long-lasting antinociceptive effect on both hind paws. The effects on the lesioned paw were clearly and statistically more potent than for the non-lesioned paw. The selective antinociceptive effect of 2 mg/kg DAMGO, 3 mg/kg BUBU and 1.5 mg/kg U 69593 were completely prevented by prior administration of the appropriate antagonists: 0.1 mg/kg naloxone, 1 mg/kg naltrindole and 0.4 mg/kg MR 2266. The present data clearly show that an acute i.v. injection of these selective opioid agonists induces potent antinociceptive effects in a rat model of peripheral neuropathy. These data are discussed with regard to the classical view that there is opioid resistance in neuropathic pain.