Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na
- Resource Type
- Authors
- Thilo, Focken; Kristen, Burford; Michael E, Grimwood; Alla, Zenova; Jean-Christophe, Andrez; Wei, Gong; Michael, Wilson; Matt, Taron; Shannon, Decker; Verner, Lofstrand; Sultan, Chowdhury; Noah, Shuart; Sophia, Lin; Samuel J, Goodchild; Clint, Young; Maegan, Soriano; Parisa K, Tari; Matthew, Waldbrook; Karen, Nelkenbrecher; Rainbow, Kwan; Andrea, Lindgren; Gina, de Boer; Stephanie, Lee; Luis, Sojo; Robert J, DeVita; Charles J, Cohen; Steven S, Wesolowski; J P, Johnson; Christoph M, Dehnhardt; James R, Empfield
- Source
- Journal of medicinal chemistry. 62(21)
- Subject
- Central Nervous System
Models, Molecular
Epilepsy
Hep G2 Cells
Amides
Madin Darby Canine Kidney Cells
Mice
Structure-Activity Relationship
Dogs
Protein Domains
NAV1.6 Voltage-Gated Sodium Channel
Animals
Humans
Protein Isoforms
Sodium Channel Blockers
- Language
- ISSN
- 1520-4804
Nonselective antagonists of voltage-gated sodium (Na