Parental age, genetic mutation, and cerebral palsy
- Resource Type
- Authors
- N A Fletcher; J Foley
- Source
- Subject
- Adult
Pediatrics
medicine.medical_specialty
medicine.risk_factor
Adolescent
Hemiplegia
Quadriplegia
Paternal Age
Cerebral palsy
Genetics
Paralysis
Medicine
Humans
Spasticity
Paternal age effect
Athetosis
Genetics (clinical)
Genes, Dominant
Hemiplegic cerebral palsy
business.industry
Cerebral Palsy
Diplegia
Infant, Newborn
Middle Aged
medicine.disease
nervous system diseases
Dystonia
Mutation
medicine.symptom
Birth Order
business
Spastic quadriplegia
Research Article
Maternal Age
- Language
- English
Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.