Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection
- Resource Type
- Authors
- Ma Michelle Demogina Penaranda; Ingvill Jensen; Hanna L. Thim; Guro Strandskog; Shiferaw Jenberie; Jorunn B. Jørgensen; Morten Bay Styrvold
- Source
- Frontiers in Immunology, Vol 11 (2020)
- Subject
- lcsh:Immunologic diseases. Allergy
0301 basic medicine
Atlantic salmon
animal diseases
Immunology
Spleen
Alphavirus
Salmonid alphavirus
03 medical and health sciences
Peritoneal cavity
0302 clinical medicine
Immune system
medicine
Immunology and Allergy
Salmo
Neutralizing antibody
B cell
VDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920
B cells
VDP::Agriculture and fishery disciplines: 900::Fisheries science: 920
teleost
biology
biology.organism_classification
Acquired immune system
030104 developmental biology
medicine.anatomical_structure
antibody secreting cells
peritoneal cavity
biology.protein
lcsh:RC581-607
030215 immunology
- Language
- English
B cell responses are a crucial part of the adaptive immune response to viral infection. Infection by salmonid alphavirus subtype 3 (SAV3) causes pancreas disease (PD) in Atlantic salmon (Salmo salar) and is a serious concern to the aquaculture industry. In this study, we have used intraperitoneal (IP) infection with SAV3 as a model to characterize local B cell responses in the peritoneal cavity (PerC) and systemic immune tissues (head kidney/spleen). Intraperitoneal administration of vaccines is common in Atlantic salmon and understanding more about the local PerC B cell response is fundamental. Intraperitoneal SAV3 infection clearly induced PerC B cell responses as assessed by increased frequency of IgM+ B cells and total IgM secreting cells (ASC). These PerC responses were prolonged up to nine weeks post-infection and positively correlated to the anti-SAV3 E2 and to neutralizing antibody responses in serum. For the systemic immune sites, virus-induced changes in B cell responses were more modest or decreased compared to controls in the same period. Collectively, data reported herein indicated that PerC could serve as a peripheral immunological site by providing a niche for prolonged maintenance of the ASC response in Atlantic salmon.