This chapter aggregates information on the consequences of burnout in physicians across the continuum of education and practice, including estimates on the impact of burnout on the US health care system. Consequences include increased sick days (absenteeism), lower professional effectiveness in the workplace (presenteeism), reduced participation in team-based models of care, lower quality of care, and higher rates of errors. Physician burnout affects individual physician experience, well-being, and professional fulfillment. Burnout has important consequences for patient experience, quality of patient care, and the work experience of the interprofessional team. Burnout in attending physicians and residents may contribute to burnout and cynicism in medical students. Finally, due to effects on workforce turnover, burnout has great costs to both the health care system and society.