Locomotion and proliferation of glioblastoma cells in vitro: statistical evaluation of videomicroscopic observations
- Resource Type
- Authors
- Ilona Fazekas; Emília Madarász; Balazs Hegedus; Tamás Vicsek; Tamás Bábel; Andras Czirok
- Source
- Scopus-Elsevier
- Subject
- Cell
Motility
FOS: Physical sciences
In Vitro Techniques
Andrology
Cell Movement
Image Processing, Computer-Assisted
Tumor Cells, Cultured
Medicine
Humans
Physics - Biological Physics
Microscopy, Video
business.industry
Cell growth
Brain Neoplasms
Equipment Design
Cell cycle
medicine.disease
In vitro
Quantitative Biology
On cells
medicine.anatomical_structure
Cell culture
Biological Physics (physics.bio-ph)
Data Interpretation, Statistical
FOS: Biological sciences
business
Glioblastoma
Neuroscience
Cell Division
Quantitative Biology (q-bio)
- Language
Long-term videomicroscopy and computer-aided statistical analysis were used to determine some characteristic parameters of in vitro cell motility and proliferation in three established cell lines derived from human glioblastoma tumors. Migration and proliferation activities were compared among the three cell lines since these are two features of tumor cells that strongly influence the progression of cancer. The results on these dynamical parameters of cell locomotion were compared to pathological data obtained by traditional methods. The data indicate that the analysis of cell motility provides more specific information and is potentially useful in diagnosis.
Comment: 16 pages incl. figures