Association of vitamin D receptor Taq I polymorphism and susceptibility to oral squamous cell carcinoma
- Resource Type
- Authors
- Kivanç, Bektas-Kayhan; Meral, Unür; Ilhan, Yaylim-Eraltan; H Arzu, Ergen; Bahar, Toptas; Günter, Hafiz; Ahmet, Karadeniz; Turgay, Isbir
- Source
- In vivo (Athens, Greece). 24(5)
- Subject
- Adult
Male
Genotype
Middle Aged
Risk Factors
Case-Control Studies
Carcinoma, Squamous Cell
Humans
Receptors, Calcitriol
Female
Genetic Predisposition to Disease
Mouth Neoplasms
Polymorphism, Restriction Fragment Length
Aged
- Language
- ISSN
- 1791-7549
It has been hypothesised that vitamin D receptor (VDR) gene polymorphisms may influence both the risk of cancer occurrence and prognosis.The distribution of VDR Taq I polymorphism in 64 patients with OSCC was determined by polymerase chain reaction based restriction fragment length polymorphism (RFLP) and compared with that of 87 healthy controls.There was a significant difference in the distribution of VDR Taq I genotypes between OSCC patients and healthy controls. Patients with the VDR Tt genotype were found to be at significantly higher risk for OSCC than those with other genotypes (p=0.036). In particular, female OSCC patients were at higher risk (p0.001) for oral cancer.These results suggest that the VDR Taq I polymorphism may be associated with susceptibility to OSCC. Female predilection of the OSCC risk in association with VDR gene polymorphism should also be investigated.