Additional file2: Figure S1. DRB18 binds to GLUT2-4 in outward open conformation. Figure S2. DRB18 docked to hGLUT1-4 in inward open conformation. Figure S3. DRB18 treatment leads to induced internalization of glucose via different endocytic mechanisms. FigureS4. DRB18 caused G1/S phase cell cycle arrest and necrotic cell death in A549 cells. Figure S5. Average body weights of nude mice bearing A549 xenograft tumors from control (n=10) and DRB18 (n=10) treated groups.