The Heads Up: Concussions in High School Sports Program is a nationwide initiative established by the Centers for Disease Control and Prevention, which aims to reduce the risks of concussions and other severe head injuries for youth athletes. Heads Up targets schools as central distributors for concussion/head-injury awareness and prevention by educating stakeholders. The Centers for Disease Control and Prevention’s Heads Up program has joined the National Federation of State High School Association in its efforts to educate and improve awareness and management of concussion through a free online training course for stakeholders of high school sports. This course, along with other publicly available resources and toolkits, are designed and tailored to educate stakeholders of all high school sports with the purpose of assisting in the implementation of safety protocols for young athletes. The Heads Up: Concussion in High School Sports initiative is a nationwide success that encompasses multiple evidence-informed components and, therefore, prevails as an exemplary practice in sports and injury prevention programs designed for recreational activities.