Brain gray matter volume associations with gait speed and related structural covariance networks in cognitively healthy individuals and in patients with mild cognitive impairment: A cross-sectional study
- Resource Type
- Authors
- Beauchet, Olivier; Montembeault, Maxime; Barden, John M; Szturm, Tony; Bherer, Louis; Liu-Ambrose, Teresa; Chester, Victoria L; Li, Karen; Helbostad, Jorunn L; Allali, Gilles; Canadian Gait Consortium
- Source
- Experimental Gerontology, Vol. 122 (2019) pp. 116-122
- Subject
- Male
0301 basic medicine
Aging
medicine.medical_specialty
Cognitive disorders
Cross-sectional study
Striatum
behavioral disciplines and activities
Biochemistry
Gait speed
03 medical and health sciences
Motor control
Imaging, Three-Dimensional
0302 clinical medicine
Endocrinology
Physical medicine and rehabilitation
Image Interpretation, Computer-Assisted
mental disorders
Genetics
Humans
Medicine
Cognitive Dysfunction
In patient
Gray Matter
Cognitive impairment
Gait
Molecular Biology
Aged
Brain Mapping
business.industry
Organ Size
Cell Biology
Magnetic Resonance Imaging
ddc:616.8
Walking Speed
Cross-Sectional Studies
030104 developmental biology
Healthy individuals
Female
Brain Gray Matter
business
human activities
Software
030217 neurology & neurosurgery
MRI
- Language
- ISSN
- 0531-5565
Introduction Gait speed is slower in patients with mild cognitive impairment (MCI) compared to cognitively healthy individuals (CHI). We examined the patterns of brain gray matter (GM) volume association and covariance with gait speed in CHI and in patients with MCI. Methods A total of 96 CHI and 99 patients with MCI were recruited in this cross-sectional study. Brain GM volumes measured with voxel-based morphometry and self-paced gait speed were used as outcomes. Results The right middle frontal and precentral gyri volumes were positively associated with gait speed in CHI and covariated with frontal cortex. Striatum (i.e. left putamen and bilateral caudate nuclei) volumes were positively associated with gait speed in patients with MCI and covariated with striatal structures. Conclusions Two different patterns of brain GM volume association and covariance with gait speed were found and involving frontal cortex in CHI and the striatum in patients with MCI.