Additional file 4: Fig. S1. Comparison of the CSF proteomes of the two App knock-in models reveals alterations in ECM proteins. a Volcano plots displaying the changes in protein levels in CSF from AppNL-F/NL-F vs AppNL-G-F/NL-G-F mice. Dash line: p = 0.05. b Heatmap of significantly (p < 0.05) altered proteins in AppNL-F/NL-F mice as compared to AppNL-G-F/NL-G-F mice. Proteins were sorted into upregulated and downregulated proteins in the AppNL-G-F/NL-G-F mice and by significance from highest to lowest (top to bottom).