Development of a Laboratory Animal Model for Functional Studies of three Human Pregnancy Proteins: α-Foetoprotein (AFP), β-Glycoprotein (SP-l) and Pregnancy Zone Protein (PZP)
- Resource Type
- Authors
- Hau, J
- Source
- Subject
- embryonic structures
- Language
- English
A murine model for the study of the function of three human pregnancy-associated serum proteins has been developed. The human proteins are pregnancy zone protein (PZP) of maternal origin, pregnancy-specific β1-glycoprotein (SPil) of placental origin and ocfoetoprotein (AFP) of foetal origin. The maternal serum levels of murine SP-l (PAMP-2) and murine AFP during pregnancy reflect the growth of the placenta and foetuses respectively, indicating the usefulness of the model in teratogenic studies.
Scandinavian Journal of Laboratory Animal Sciences, Vol. 11 No. 2 (1984)