Regio- and Stereoselective Photoredox-Catalyzed Atom Transfer Radical Addition of Thiosulfonates to Aryl Alkynes
- Resource Type
- Authors
- Hui Zhang; Zhiyuan Peng; Haolin Yin; Tiezheng Jia
- Source
- Organic Letters. 22:5885-5889
- Subject
- 010405 organic chemistry
Chemistry
Atom-transfer radical-polymerization
Aryl
Organic Chemistry
Regioselectivity
010402 general chemistry
01 natural sciences
Biochemistry
Combinatorial chemistry
0104 chemical sciences
Catalysis
chemistry.chemical_compound
Stereoselectivity
Physical and Theoretical Chemistry
Thiyl radicals
- Language
- ISSN
- 1523-7052
1523-7060
Despite extensive investigations, altering the regioselectivity of atom transfer radical addition (ATRA) to alkynes remains a highly desirable yet unachieved challenge. Guided by computational predictions, thiosulfonates were found herein as a tunable radical precursor for thiyl radicals instead of well-recognized sulfonyl radicals. Merging such a finding with ATRA to phenylacetylenes leads to a highly regio- and stereoselective approach to (