MiR-486-3p targeting ECM1 represses cell proliferation and metastasis in cervical cancer
- Resource Type
- Authors
- Xiaoping Tang; Feng Chen; Haiqiong Ye; Jiyi Xia; Xiaolan Yu; Li Tang
- Source
- Biomedicine & Pharmacotherapy. 80:109-114
- Subject
- 0301 basic medicine
Oncology
medicine.medical_specialty
Down-Regulation
Uterine Cervical Neoplasms
Metastasis
law.invention
03 medical and health sciences
0302 clinical medicine
law
Cell Line, Tumor
Internal medicine
microRNA
Gene expression
medicine
Humans
Neoplasm Metastasis
Cell Proliferation
Oligonucleotide Array Sequence Analysis
Pharmacology
Cervical cancer
Extracellular Matrix Proteins
Base Sequence
Cell growth
business.industry
General Medicine
medicine.disease
Gene Expression Regulation, Neoplastic
MicroRNAs
030104 developmental biology
030220 oncology & carcinogenesis
Molecular mechanism
Suppressor
Female
Target gene
business
- Language
- ISSN
- 0753-3322
MicroRNAs (miRNAs) regulate gene expression and are involved in cervical cancer. But the molecular mechanism is still unclear. Here, miRNA profile of cervical cancer was performed and demonstrated that miR-486-3p decreased in specimens of cervical cancer patients. In addition, our clinical data show that decreased miR-486-3p was associated with metastasis in cervical cancer patients. ECM1 was predicted and velified as a target gene of miR-486-3p. Overexpression of miR-486-3p inhibited cell growth and metastasis by targeting ECM1. In a conclusion, these findings suggest that miR-486-3p is a tumor suppressor miRNA and induction of miR-486-3p is a potential strategy to inhibit cervical cancer progression.